Mother of God Church was established in Southfield in 1948. The current edifice was designed in a Byzantine Revival style and completed in 1980. Two years later, the church became a Chaldean cathedral when the Eparchy of St. Thomas the Apostle was established.
Stained-glass windows in the dome depict, left to right: St. Peter and St. Paul; St Joseph and Child Jesus; Blessed Virgin Mary and Child Jesus; St. Thomas the Apostle; St. Addai and St. Mari. Like many churches, the Last Supper is depicted on the facade of the altar.
The Sacred Heart of Jesus and Blessed Virgin Mary are depicted at side altars.
Stations of the Cross hang beneath windows that depict Gospel scenes.
Two plaques hang in the vestibule, one depiction of the Sacred Heart of Jesus as well as Madonna and Child.
St. Joseph with Child Jesus and St. Rita at the northern end of the vestibule.
St. Anthony with Child Jesus and St. Padre Pio at the southern end of the vestibule.
Many doors are engraved with a large crucifix; a statue of the Holy Family stands outside the church.
A statue of the Blessed Virgin Mary stands in a courtyard outside the cathedral.